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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4456f48b599b5ae49fe27bf80f28441b1787b900231baf7494aed35e03b21e45' 
  AND token = 's6vLlpyPaH3dVc/L98DksPcI9XuFT/f1zo49CXt3ILU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}