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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed354eb8aa28913a30cd10640c2dbd2dccdf4068bff25ac12f053c39002278c3' 
  AND token = '4MPeQVZXaTL9NQjIPWGjiDQsgLz2y7wLXQ/JitRW2ms=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}