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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b9f8c273ca548d31d594e92e6a236992a6e10d1e88a58751f843a2843d0473' 
  AND token = 'zXtdqQietLJ3wQogtQFz+r6mlAIq4ibyAQSE5NpCPeE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}