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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72506c257a125ebf8ca4910ca607d1357f3aac38769ddb6e9bdeb7107d2a5b03' 
  AND token = 'K8NXqJ9W/y9HZcyQEvY6vrDKaNzypTCWO1CahSNrf5o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}