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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4734e27230b5d1eb31c87ce35be7c7067e844583cb4987b1e61f2200c245f722' 
  AND token = '9/d5d9GtBZ4/gmxmgQrqZ+f2CQtGKbYiR+qaYpXZGEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}