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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ad4757c59f2d33f3bbcb7d20a0ce2497aa338a3cd170716a669b748303c9100' 
  AND token = 'Yz2oOiW0/Hywp0qg6SZ8uKnudiAGm4uRPnDpPFGWRr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}