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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e1477475e199fe1eeaa960818f675d748adb1a4995c78066dea5a781bf2c4d5' 
  AND token = 'hWbE4e6YX3DmtxefO3svcFpDQoqBT5dsmktL509rW9M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}