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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '142b57c9481fae8961654c1f537d4b7e93d3857d1d7d1fef4fbd6c506a401d17' 
  AND token = 'ApZs8P+QKbq+jxoOcD7p0UK0f8tXm6d0jc+D+DUTtX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}