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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '783ef7fe200b9cad3777163982c8950fc3386912baa42a8cca9fc1856abe48c3' 
  AND token = 'aJDTay88UgL2BbQuVAbN6j44yg5MTRmcWjOnEgN9V2s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}