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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b27bf395d3a8bbabc3b249dd9b111d125762aec32d66a22b20ab84adc4e2383c' 
  AND token = '3sTF8Y1hAH3EAk3/5+Wkg+DeCuSVx+PquKdHzSMa7cQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}