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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4a5bd0412cbe7e221a9901d35587b500c0f9d6c56c0dea7ce2ac501d3531604' 
  AND token = 'XlFfnyzaaQX/YWdysRV8ain6eHSx4Fdl9IdUX3SA9xU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}