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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bb4824fb84c239082a6a49d75b76bce7df18910dbf57b316d82d8d7609118147' 
  AND token = 'S5rqcPIsAvAHMQdQ1v4qlwFh0oWoCczMGrHL1UG78Gs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}