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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a18aad4995cd4317361945b709fb1378fd7dab1a6b8de06b15c6d8820de4a275' 
  AND token = 'VZLJRE71nkKpWE03EtEX/tCkHkn22TpBAfgdQiDevjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}