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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e78122163a3438ec229d2242353555918e2ccc5fc5b84c0849367b1696e559b5' 
  AND token = 'u18pazw0OCn/o3bOPMW38kuDkou6+CEqafSFBYvYRkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}