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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c496c8951f9876f88b5180c8db12d0a4221b37e3aceda712ca63421389842469' 
  AND token = '3I8jStnUrWC2OWUAHZnhBZMRvUQgVHEhEFPgdFASejs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}