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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d003be16356cae2b18238918c098d202a54122f53bc7d89514237fa901a2588' 
  AND token = 'BAmvo+SFGJDDuCzub9a8UmLbpsoLQL+QA77UzdeJ3qs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}