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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5c2388437bba5d6ee9fe3d2e977648e2eda07968ca82307e6746bd0fc94c99a' 
  AND token = 'eXKV/JTWsT8/Dw+dCQKGiDtDjdVv2v+n23d8Ym6MSs0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}