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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43468a8a99653cc0c0a8546f73ba7f177120a78635bf05d9f17b8e7e177a3f8d' 
  AND token = 'L9LS1MCMWWwlZ8D9cxAJ0fZXbTG7A7OAST0Z3muPQJU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}