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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb67606c79d778095403564fd1d1743d388fef551e0fdca5c191fcb43b409e00' 
  AND token = 'F+trwLTrQvQdVjet6AumsilxaZcKqjXn81PRTezACzc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}