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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a7ce2f9c4b26bc65c233fd8d9583ec82378d63f27c63432ba00b2de2762f564' 
  AND token = 'SjsINOFN51Rp8nPb4pLxLGZ6sipCYcVIDgSUwKn2lA8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}