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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fcadd5cbab33810d38585d99a84f99bde77cb3406ba7c9748a696f7880e5c0f' 
  AND token = 'VTHN3FSP39flFXdzF8qTrFhbtUtZf/xkMAZWEwEBAI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}