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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '290740dcf262bb321f12cab552d04c0f9415d91db3e8c68b595daad302af049c' 
  AND token = 'S6SP7mD+ou7Kxn04OJyoQxmhYFO0uN4wEmRIuXo+ZjE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}