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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e49b80ede73e3f3e46f7616a1e849a6cfd86fd17631b56220e0d0cd727f0f68' 
  AND token = 'd7sU5thIT513udmoJIDOGj2fTBUa4G3d3dpfH6XjLx8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}