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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54273a7f0d1fac74077acec1447718ab1ef6b0b7145f03adb8f08333d8b123f7' 
  AND token = 'r4qPE9Dkqcyx2KRxBiTXV1aBwjCrQJAaRRRUGNshw+o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}