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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54e7eb72f67843b5609f2f24bf6fda818d774f87eb8fc71f7f0929d1fdb44173' 
  AND token = 'lsMgDSZs/wcUyHDYMee8TFGbUVNiCR9rwtbeKTwYN3w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}