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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ca34b8d0d361ccf349a4d648701bed5dcbd002f87df51400a4185f02a3b31a' 
  AND token = '3yiHIwI0J9KX3vlKFfk6LGq007qAS+fabz529JnGVsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}