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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c57cc11ae13ca5a5d15b0da7811bd889103b67ac187218c824cec83551c056da' 
  AND token = 'XCVqb0J3EjQXPwiW/HYEqMizM2zWcjXC07LOa+0hGAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}