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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49cddb963a8d181c7f58139da34f0feda24fcf7b48aa1e532e769d386f7a83d7' 
  AND token = 'ZHQuDfMX85Dq2aivnnKXGwyZ+GIDwpNdq0L7CgPcQWA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}