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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f4b7348dc678b40ecb2f63890652518f53a8c238c8f5b49e7be10aafffc804' 
  AND token = 'vaSWldhi+fb1fQrKMZWofcECwrnNiNGYgyQ9NsRVMmg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}