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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '650368df83a78e4cb37c17a97207f75c74497ad90f450ab296295c8f99b5abf9' 
  AND token = 'm1BpmWqy9IHG6fNMjOrP8ex4sIJxCDREvRXvAUcMWQo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}