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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7acfb129269d852ee1c23d5ee2710991f37712379b8d91531a177561e8ae9dac' 
  AND token = 'tkdpBk2mqdTc+fM3GQ+P+fkNS9Wv1qspyPIvOfN011I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}