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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de8aef51d849af668ac4fb4669a003902e657c1508433412a839c3b704ce6be2' 
  AND token = '2JAwSNe73egSKQc8u4pPCpDPfN5farlf5eyNLnQGuzo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}