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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8880d4b4c6285fedf0b45110ddd957d80e6f34c21076558ecb88107c10b7d1ae' 
  AND token = 'PzuCyU6PAnTbJjSPlh05lmgjSOm5cm7Y3zdvBlkFQXs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}