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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5a72c0613951b3c64a5186ffc78c48e12e7e121581e9c65fb2e21bf9dd77b43' 
  AND token = 'TU4XNctOnAAi/5G+49LunggXaP43UZn1Hs1BY0zjk78=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}