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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6dfdb19971e604fd8a2f46039c95b5a6e22e99969f5995f1877fe593b52da15' 
  AND token = 'UQNYsETVjwEyjfWTnQsFCMkVELVxCupMZm29qm6yvxA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}