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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d80bb7dc78f3aa7a4f1c05f7875860ea64f14747ed8e61e8f5175ff73b68210' 
  AND token = 'fmQiO7Edvlv+h4fBgPoamMwlT7iO6FXaoZH+y7bYwMg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}