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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b9dc5862e25c0a4721c763ae1329e5997d67b8f9ca0800e32f8f83376058b3f' 
  AND token = 'QEloV9zHYTcnnqRmQQtEIGqGp8SXTwotg1RwJO7UCdc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}