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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4180e664d425e7ac225ceaa1c6a41f90f0195e1de0fce92f49377f5a7b11a1c7' 
  AND token = 'R6Q1p+FNXoA7lQj9fpMO7Jxld039bKwX4iKYNmjipcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}