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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38d64f8b4ae1caf3a884b63d43a443d01c65c4fe46240a66091b009c27099382' 
  AND token = 'dez4bLAaPErmZLtFyIGawfz2i23K7+dw1Y9Ap7TX0vg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}