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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c27955f2c3b8de5aa22594788e6e9f33dc68fc07d24cfceec388dbbf35b2e80' 
  AND token = 'Aumeh++LHeSxACxpXSvN3gkeu4Z2hE/vVWiuBGTN2PE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}