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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'db78f3ce6a2bf6f521f5e65ffcb2ef0c4d1bad45c8d0c44227c8acc148febfe3' 
  AND token = '66XGjAUyVIazNAV2jxur9T3hJXaX88ICRnVW0G8V250=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}