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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a1edf735acdf518358628b5b2f0724b60814c16bffeda2110006a1a47d22f76' 
  AND token = 'ndgrDGPh8gyM9mUxT1uTK/4txc7jGjR/BuTj1AkL+fo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}