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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f3fe22a3fc6ffd36db37bce72707984bb0bf2621dd341c12b611838ea4163b' 
  AND token = '46SD+qkUeHj/B6pPA25bI3hwMMxSsU3U1Feo+8p8pNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}