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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a1333708b0186596474e06710e8854314b2f01103cc8dc0a9549d59a4da72ce2' 
  AND token = 'S6u9T/OkvJ/778WAWvs2dbI05BBDaVEMmOmgw9CZY5E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}