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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53dbf46f0c228eb7bff312fc63f52a99864441666a63872b82238ffbfda8ea19' 
  AND token = 'wQTCkUMOTIdWI95NhTR3fHAGvJt+DMSsDI1me3LkoXE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}