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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e0fb96a7e857381582ea405b0f4162644c6eb825b2644151c20028baf38561c' 
  AND token = 'HRfxarR6zxoBJ8aFQmmatQyDFBfBD51SQ7vMOzB7GgU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}