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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c2294c36b6949eb6116be5d125b62267e9ebcb0b620b9e4e62ce01188aa15c4' 
  AND token = 'WpdsJFem9vAm2+uplWCrT0kI9Ni1CKtLCdEqBR2O900=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}