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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81083faf19d10c6544bacd2df33bc02735ff58f27512e77aa0fd47fe54f12d75' 
  AND token = 'qyC9Nu/7cz26lbBDlccfXFvzP1/9k4Hi9AGnqhPg4TY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}