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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e60d107bfc84161d0492ba1d9a1a1ced607307864d533a74fca6808b75c401da' 
  AND token = 'Vvia2i+tGhtv7SXd+EWrIM4aicP85+apRWlTTxtyTzI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}