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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4b3b28f22f75c7ca9602363249ddf1a37c7fbe764edf473c03df81d72be5538' 
  AND token = 'e+7cgofCIb4KD6wpRxbY/s8PZD1+tYOcHIvR45AyOE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}